Technology
From small-volume research to industrial production, we rebuild filtration around one process logic.
Two scales, two different problems
Small-volume processing serves research, process development and personalised therapies: samples are a few millilitres or less, high in value and many in number. It needs small volumes, low loss and reproducibility — and the process data produced here has to be able to support scale-up later.
Large-volume processing serves precision fermentation and industrial biomanufacturing: higher output per unit of capacity, longer continuous operating time, lower capital and operating cost, and fewer manual interventions and intermediate steps.
The physical constraints differ, and scaling one architecture up or down does not resolve both. We start with small volume — it is where the process chain begins, and where existing solutions fit least well.
Scalable small-volume filtration
Low-volume tangential flow filtration — why existing equipment is a poor fit, and where we started instead.
Not scalable, hard to control
Methods common at the research stage — concentrating in ultrafiltration spin tubes, for example — do not scale reliably. At transfer, the process often has to be developed again from scratch.
Minimum volume mismatch
Systems on the market generally have a minimum working volume above 10 mL. For high-value samples of a few millilitres or less, being forced into an unnecessary batch size wastes both sample and consumables.
Manual operation
The smaller the volume, the more pump vibration interferes with conventional monitoring such as balances. The run then needs watching throughout — levels, pressure by hand, endpoint by judgement — and the operator becomes the main source of variability.
Designed from first principles
We didn't start from an existing product. We started from the question: what structure does tangential flow filtration actually need at half a millilitre?
- Shorter flow paths, lower hold-up — dead volume comes mostly from tubing length and fitting count. We redesigned the holder that fixes the hollow fiber module, adding a degree of rotational freedom so the tubing can be shortened and hold-up reduced.
- Smaller hollow fiber filters — membrane area matched to sample volume rather than a filter longer than the job needs; this lowers hold-up further and reduces product adsorption on the membrane surface, improving recovery.
- Pressure regulated by flow path design — passive pressure control through tubing dimensions and flow matching, not operator adjustment.
- Better weight monitoring — a filtrate line support partially isolates pump vibration from the filtrate balance, giving more accurate weight readings, reliable endpoint detection and automatic stop, with no manual judgement.
Where it's used
LNP & RNA therapeutics
Concentration, desalting and buffer exchange for LNPs, mRNA and plasmid DNA.
Exosomes & EVs
Low-shear enrichment and purification that preserves vesicle integrity and activity.
Viral vectors
Gentle concentration and buffer exchange for AAV, lentivirus and related vectors.
Proteins & antibodies
Concentration, desalting and formulation buffer exchange for recombinant proteins and antibodies.
Nanomedicines
Washing, concentration and media exchange for drug delivery particles.
A faster alternative to dialysis
Complete buffer exchange in hours rather than days.
We build our industrial bioproduction platform around three directions
Fit-for-Scale
Fit-for-Scale
One filtration platform covering research, small scale, pilot and commercial — sized right at each stage, with smooth scale-up between them.
Process Intensification
Process Intensification
Higher efficiency and lower input from the same equipment footprint, through better filtration and intelligent control.
Continuous Processing
Continuous Processing
Filtration, concentration and purification integrated into a continuous flow, reducing intermediate storage and monitoring steps.